PUBLICATION
Zebrafish: A model system for the study of eye genetics
- Authors
- Fadool, J.M., and Dowling, J.E.
- ID
- ZDB-PUB-071029-13
- Date
- 2008
- Source
- Progress in Retinal and Eye Research 27(1): 89-110 (Journal)
- Registered Authors
- Dowling, John E., Fadool, James M.
- Keywords
- Zebrafish genetics, Retina, Lens, Development, Disease
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Eye Diseases/genetics*
- Genetic Techniques
- Zebrafish/genetics*
- PubMed
- 17962065 Full text @ Prog. Retin. Eye Res.
Citation
Fadool, J.M., and Dowling, J.E. (2008) Zebrafish: A model system for the study of eye genetics. Progress in Retinal and Eye Research. 27(1):89-110.
Abstract
Over the last decade, the use of the zebrafish as a genetic model has moved beyond the proof-of-concept for the analysis of vertebrate embryonic development to demonstrated utility as a mainstream model organism for the understanding of human disease. The initial identification of a variety of zebrafish mutations affecting the eye and retina, and the subsequent cloning of mutated genes have revealed cellular, molecular and physiological processes fundamental to visual system development. With the increasing development of genetic manipulations, sophisticated techniques for phenotypic characterization, behavioral approaches and screening strategies, the identification of novel genes or novel gene functions will have important implications for our understanding of human eye diseases, pathogenesis, and treatment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping