PUBLICATION

Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development

Authors
Manfroid, I., Delporte, F., Baudhuin, A., Motte, P., Neumann, C.J., Voz, M.L., Martial, J.A., and Peers, B.
ID
ZDB-PUB-071023-19
Date
2007
Source
Development (Cambridge, England)   134(22): 4011-4021 (Journal)
Registered Authors
Baudhuin, Ariane, Delporte, Francois, Manfroid, Isabelle, Martial, Joseph A., Neumann, Carl J., Peers, Bernard, Voz, Marianne
Keywords
none
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Cell Communication/physiology
  • Cell Differentiation
  • Embryo, Nonmammalian
  • Endoderm/metabolism
  • Endoderm/physiology*
  • Fibroblast Growth Factor 10
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/physiology*
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins/genetics
  • Homeodomain Proteins/metabolism
  • LIM-Homeodomain Proteins
  • Mesoderm/metabolism
  • Mesoderm/physiology*
  • Models, Biological
  • Organ Specificity
  • Pancreas/embryology*
  • Pancreas/metabolism
  • Signal Transduction/genetics
  • Transcription Factors
  • Zebrafish/embryology
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • Zebrafish Proteins/physiology*
PubMed
17942484 Full text @ Development
Abstract
In amniotes, the pancreatic mesenchyme plays a crucial role in pancreatic epithelium growth, notably through the secretion of fibroblast growth factors. However, the factors involved in the formation of the pancreatic mesenchyme are still largely unknown. In this study, we characterize, in zebrafish embryos, the pancreatic lateral plate mesoderm, which is located adjacent to the ventral pancreatic bud and is essential for its specification and growth. We firstly show that the endoderm, by expressing the fgf24 gene at early stages, triggers the patterning of the pancreatic lateral plate mesoderm. Based on the expression of isl1, fgf10 and meis genes, this tissue is analogous to the murine pancreatic mesenchyme. Secondly, Fgf10 acts redundantly with Fgf24 in the pancreatic lateral plate mesoderm and they are both required to specify the ventral pancreas. Our results unveil sequential signaling between the endoderm and mesoderm that is critical for the specification and growth of the ventral pancreas, and explain why the zebrafish ventral pancreatic bud generates the whole exocrine tissue.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes