ZFIN ID: ZDB-PUB-071016-1
Sp1-like transcription factors are regulators of embryonic development in vertebrates
Zhao, C., and Meng, A.
Date: 2005
Source: Development, growth & differentiation   47(4): 2001-211 (Review)
Registered Authors: Meng, Anming, Zhao, Chengtian
Keywords: none
MeSH Terms:
  • Animals
  • Embryonic Development/genetics*
  • Sp1 Transcription Factor/physiology*
  • Transcription Factors/physiology*
  • Vertebrates/embryology*
  • Vertebrates/genetics
PubMed: 15921495 Full text @ Dev. Growth Diff.
Sp1-like family is an expanding transcription factor family. Members of this family bind to the GC-box or GT-box elements in the promoter/enhancers and regulate the expression of the target genes. Currently, this family consists of at least nine members, which may act as a transactivator or a repressor on target promoters. Sp1-like transcription factors are expressed during development of vertebrate embryos in ubiquitous or tissue-specific manners and play various roles in embryonic development. This review mainly summarises their expression patterns and functions during vertebrate embryogenesis.