PUBLICATION
Cellular and molecular processes of regeneration, with special emphasis on fish fins
- Authors
- Nakatani, Y., Kawakami, A., and Kudo, A.
- ID
- ZDB-PUB-070310-1
- Date
- 2007
- Source
- Development, growth & differentiation 49(2): 145-154 (Review)
- Registered Authors
- Kawakami, Atsushi
- Keywords
- none
- MeSH Terms
-
- Animals
- Extremities/blood supply
- Extremities/physiology*
- Fishes/physiology*
- Neovascularization, Physiologic
- Regeneration/physiology*
- PubMed
- 17335435 Full text @ Dev. Growth Diff.
Citation
Nakatani, Y., Kawakami, A., and Kudo, A. (2007) Cellular and molecular processes of regeneration, with special emphasis on fish fins. Development, growth & differentiation. 49(2):145-154.
Abstract
The phenomenon of 'epimorphic regeneration', a complete reformation of lost tissues and organs from adult differentiated cells, has been fascinating many biologists for many years. While most vertebrate species including humans do not have a remarkable ability for regeneration, the lower vertebrates such as urodeles and fish have exceptionally high regeneration abilities. In particular, the teleost fish has a high ability to regenerate a variety of tissues and organs including scales, muscles, spinal cord and heart among vertebrate species. Hence, an understanding of the regeneration mechanism in teleosts will provide an essential knowledge base for rational approaches to tissue and organ regeneration in mammals. In the last decade, small teleost fish such as the zebrafish and medaka have emerged as powerful animal models in which a variety of developmental, genetic and molecular approaches are applicable. In addition, rapid progress in the development of genome resources such as expressed sequence tags and genome sequences has accelerated the speed of the molecular analysis of regeneration. This review summarizes the current status of our understanding of the cellular and molecular basis of regeneration, particularly that regarding fish fins.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping