PUBLICATION
Zebrafish as a powerful vertebrate model system for in vivo studies of cell death
- Authors
- Pyati, U.J., Look, A.T., and Hammerschmidt, M.
- ID
- ZDB-PUB-070122-26
- Date
- 2007
- Source
- Seminars in Cancer Biology 17(2): 154-165 (Review)
- Registered Authors
- Hammerschmidt, Matthias, Look, A. Thomas, Pyati, Ujwal
- Keywords
- Zebrafish, Apoptosis, Development, Cancer, Degenerative diseases, Genetics
- MeSH Terms
-
- Animals
- Apoptosis/physiology
- Cell Death/physiology*
- Gene Expression Regulation, Neoplastic/genetics
- Models, Animal*
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/metabolism*
- PubMed
- 17210257 Full text @ Semin. Cancer Biol.
Citation
Pyati, U.J., Look, A.T., and Hammerschmidt, M. (2007) Zebrafish as a powerful vertebrate model system for in vivo studies of cell death. Seminars in Cancer Biology. 17(2):154-165.
Abstract
Understanding and manipulating cell death pathways are critical to our ability to treat human degenerative diseases and cancer. The zebrafish Danio rerio, a common aquatic pet, has evolved as a powerful tool for the discovery of genes regulating cellular suicide both during normal vertebrate development and after genetic or environmental insult. In this review, we describe the techniques that can be applied to studying cell death in zebrafish as well as highlighting what has been discovered so far. Finally, we discuss future perspectives in the field and how they relate to human disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping