PUBLICATION

Getting to the heart of regeneration in zebrafish

Authors
Poss, K.D.
ID
ZDB-PUB-061229-14
Date
2007
Source
Seminars in cell & developmental biology   18(1): 36-45 (Review)
Registered Authors
Poss, Kenneth D.
Keywords
Cardiac muscle, Zebrafish, Progenitor cells, Epicardium, Neovascularization, Regeneration
MeSH Terms
  • Amphibians/physiology
  • Animals
  • Heart/physiology*
  • Humans
  • Mammals/physiology
  • Models, Biological
  • Regeneration*/genetics
  • Zebrafish/genetics
  • Zebrafish/physiology*
PubMed
17178459 Full text @ Sem. Cell Dev. Biol.
Abstract
A scientific and clinical prerogative of the 21st century is to stimulate the regenerative ability of the human heart. While the mammalian heart shows little or no natural regeneration in response to injury, certain non-mammalian vertebrates possess an elevated capacity for cardiac regeneration. Adult zebrafish restore ventricular muscle removed by surgical resection, events that involve little or no scarring. Recent studies have begun to reveal cellular and molecular mechanisms of this regenerative process that have exciting implications for human cardiac biology and disease.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes