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ZFIN ID: ZDB-PUB-061221-1
Pax proteins and eye development
Macdonald, R., and Wilson, S.W.
Date: 1996
Source: Current opinion in neurobiology   6(1): 49-56 (Review)
Registered Authors: Macdonald, Rachel, Wilson, Steve
Keywords: none
MeSH Terms:
  • Animals
  • Eye/growth & development*
  • Genes/genetics*
  • Humans
  • Models, Neurological
  • Mutation
  • Phenotype
  • Transcription Factors/genetics*
PubMed: 8794051 Full text @ Curr. Opin. Neurobiol.
Homologous members of the Pax gene family are required for eye development in Drosophila and vertebrates. Despite superficial similarities in the phenotypes of vertebrates with mutations in pax-6 and Drosophila eyeless mutants, it remains uncertain whether the two proteins encoded by these genes have comparable functions. The genetic cascade triggered by eyeless leads to eye formation, whereas pax-6 is not necessary for optic vesicle formation, but is required at other stages of eye development. A second vertebrate Pax gene, pax-2, is also required during eye development and appears to play a role during closure of the choroid fissure.