PUBLICATION
Cloning and developmental expression of the Xenopus homeobox gene Xvsx1
- Authors
- D'Autilia, S., Decembrini, S., Casarosa, S., He, R.Q., Barsacchi, G., Cremisi, F.,and Andreazzoli, M.
- ID
- ZDB-PUB-061116-15
- Date
- 2006
- Source
- Development genes and evolution 216(12): 829-834 (Journal)
- Registered Authors
- Andreazzoli, Massimiliano
- Keywords
- Vsx1, Paired type homeobox, Retinogenesis, Ciliary marginal zone, Bipolar cells, Interneurons
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular*
- Embryo, Nonmammalian
- Eye Proteins/genetics
- Eye Proteins/metabolism*
- Gene Expression Regulation, Developmental*
- Genes, Homeobox*
- Molecular Sequence Data
- Protein Structure, Tertiary
- Retina/embryology
- Sequence Homology, Amino Acid
- Transcription, Genetic
- Xenopus/embryology
- Xenopus/genetics*
- PubMed
- 17103185 Full text @ Dev. Genes Evol.
Citation
D'Autilia, S., Decembrini, S., Casarosa, S., He, R.Q., Barsacchi, G., Cremisi, F.,and Andreazzoli, M. (2006) Cloning and developmental expression of the Xenopus homeobox gene Xvsx1. Development genes and evolution. 216(12):829-834.
Abstract
In contrast to the high degree of evolutionary conservation of the Vsx2/Chx10 gene family, vertebrate orthologues of Vsx1 display more divergent sequences and spatio-temporal expression patterns. Here, we report the cloning and expression pattern of Xenopus laevis Vsx1. Differently from the mouse and zebrafish orthologues, Xvsx1 transcription is activated at early neurula both in the evaginating eye vesicles and in the presumptive spinal cord. Compared to other retinal homeobox genes, such as Xrx1, Xsix3 and Xpax6, Xvsx1 is activated at a later stage; in addition, its anterior expression appears to be more specifically restricted to the retina. At tail bud stage, Xvsx1 expression in retinal progenitors persists, and its neural tube expression, which in the spinal cord corresponds to interneurons, progressively expands anteriorly reaching the midbrain-hindbrain boundary. During retinal neurogenesis, Xvsx1 expression is maintained in retinal progenitors and in a peripheral region of the ciliary marginal zone, while in the central retina, it becomes restricted to differentiated bipolar cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping