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ZFIN ID: ZDB-PUB-061108-11
The HeArt of Regeneration
Curado, S., and Stainier, D.Y.
Date: 2006
Source: Cell   127(3): 462-464 (Journal)
Registered Authors: Stainier, Didier
Keywords: none
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Animals, Outbred Strains
  • Cell Differentiation
  • Heart/physiology*
  • Heart Injuries/pathology
  • Heart Injuries/physiopathology
  • Heart Ventricles/pathology
  • Heart Ventricles/physiopathology
  • Male
  • Models, Cardiovascular
  • Myocardium/metabolism
  • Myocardium/pathology
  • Pericardium/injuries*
  • Regeneration/genetics
  • Regeneration/physiology*
  • Stem Cells/physiology*
  • Zebrafish/genetics
  • Zebrafish/physiology*
PubMed: 17081969 Full text @ Cell
Fish and amphibian hearts are known to regenerate after partial resection, but the molecular mechanisms underlying this process remain unclear. In this issue of Cell, analyze regeneration in the zebrafish heart. Their work indicates that new cardiomyocytes originate from undifferentiated progenitor cells and reveals a critical role for the epicardium, the cellular layer that covers the heart.