|ZFIN ID: ZDB-PUB-061031-8|
Extracellular modulation of BMP activity in patterning the dorsoventral axis
Little, S.C., and Mullins, M.C.
|Source:||Birth defects research. Part C, Embryo today : reviews 78(3): 224-242 (Journal)|
|Registered Authors:||Little, Shawn, Mullins, Mary C.|
|PubMed:||17061292 Full text @ Birth Defects Res. C Embryo Today|
Little, S.C., and Mullins, M.C. (2006) Extracellular modulation of BMP activity in patterning the dorsoventral axis. Birth defects research. Part C, Embryo today : reviews. 78(3):224-242.
ABSTRACTSignaling via bone morphogenetic proteins (BMPs) regulates a vast array of diverse biological processes in the developing embryo and in postembryonic life. Many insights into BMP signaling derive from studies of the BMP signaling gradients that pattern cell fates along the embryonic dorsal-ventral (DV) axis of both vertebrates and invertebrates. This review examines recent developments in the field of DV patterning by BMP signaling, focusing on extracellular modulation as a key mechanism in the formation of BMP signaling gradients in Drosophila, Xenopus, and zebrafish.
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