ZFIN ID: ZDB-PUB-061031-8
Extracellular modulation of BMP activity in patterning the dorsoventral axis
Little, S.C., and Mullins, M.C.
Date: 2006
Source: Birth defects research. Part C, Embryo today : reviews   78(3): 224-242 (Journal)
Registered Authors: Little, Shawn, Mullins, Mary C.
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning*
  • Bone Morphogenetic Protein Receptors/metabolism*
  • Bone Morphogenetic Proteins/metabolism*
  • Drosophila Proteins/genetics
  • Drosophila Proteins/metabolism
  • Drosophila melanogaster/embryology*
  • Embryo, Nonmammalian/metabolism
  • Gene Expression Regulation, Developmental
  • Signal Transduction
  • Xenopus Proteins/genetics
  • Xenopus Proteins/metabolism
  • Xenopus laevis/embryology*
  • Zebrafish/embryology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 17061292 Full text @ Birth Defects Res. C Embryo Today
Signaling via bone morphogenetic proteins (BMPs) regulates a vast array of diverse biological processes in the developing embryo and in postembryonic life. Many insights into BMP signaling derive from studies of the BMP signaling gradients that pattern cell fates along the embryonic dorsal-ventral (DV) axis of both vertebrates and invertebrates. This review examines recent developments in the field of DV patterning by BMP signaling, focusing on extracellular modulation as a key mechanism in the formation of BMP signaling gradients in Drosophila, Xenopus, and zebrafish.