PUBLICATION
Evolutionary history of the ABCB2 genomic region in teleosts
- Authors
- Palti, Y., Rodriguez, M.F., Gahr, S.A., and Hansen, J.D.
- ID
- ZDB-PUB-061031-2
- Date
- 2007
- Source
- Developmental and comparative immunology 31(5): 483-498 (Journal)
- Registered Authors
- Keywords
- ABCB2, Duplication, MHC, Genomic sequence, Teleost, Oncorhynchus mykiss
- MeSH Terms
-
- ATP-Binding Cassette Transporters/genetics*
- Amino Acid Sequence
- Animals
- Contig Mapping
- Evolution, Molecular*
- Fishes/genetics*
- GTPase-Activating Proteins/genetics
- Gene Duplication
- Gene Expression Profiling
- Gene Order
- Humans
- Intracellular Signaling Peptides and Proteins/genetics
- Major Histocompatibility Complex/genetics*
- Models, Genetic
- Molecular Sequence Data
- Oncorhynchus mykiss/genetics
- Phylogeny
- Protein Serine-Threonine Kinases/genetics
- Proto-Oncogene Proteins/genetics
- Receptors, Notch/genetics
- Sequence Homology, Amino Acid
- Synteny
- Transcription Factors/genetics
- Zebrafish/genetics
- rab GTP-Binding Proteins/genetics
- PubMed
- 17055577 Full text @ Dev. Comp. Immunol.
Citation
Palti, Y., Rodriguez, M.F., Gahr, S.A., and Hansen, J.D. (2007) Evolutionary history of the ABCB2 genomic region in teleosts. Developmental and comparative immunology. 31(5):483-498.
Abstract
Gene duplication, silencing and translocation have all been implicated in shaping the unique genomic architecture of the teleost MH regions. Previously, we demonstrated that trout possess five unlinked regions encoding MH genes. One of these regions harbors ABCB2 which in all other vertebrates classes is found in the MHC class II region. In this study, we sequenced a BAC contig for the trout ABCB2 region. Analysis of this region revealed the presence of genes homologous to those located in the human class II (ABCB2, BRD2, psiDAA), extended class II (RGL2, PHF1, SYGP1) and class III (PBX2, Notch-L) regions. The organizatin and syntenic relationships of this region were then compared to similar regions in humans, Tetraodon and zebrafish to learn more about the evolutionary history of this region. Our analysis indicates that this region was generated during the teleost-specific duplication event while also providing insight about potential MH paralogous regions in teleosts.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping