PUBLICATION
Mechanics and function in heart morphogenesis
- Authors
- Bartman, T., and Hove, J.
- ID
- ZDB-PUB-060825-1
- Date
- 2005
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 233(2): 373-381 (Review)
- Registered Authors
- Bartman, Thomas, Hove, Jay R.
- Keywords
- cardiac morphogenesis, shear stress, myocardial function
- MeSH Terms
-
- Animals
- Heart/embryology*
- Heart/physiology*
- Heart/physiopathology
- Heart Defects, Congenital/embryology
- Heart Defects, Congenital/physiopathology
- Heart Valves/embryology
- Heart Valves/physiology
- Humans
- Morphogenesis*
- PubMed
- 15830382 Full text @ Dev. Dyn.
Citation
Bartman, T., and Hove, J. (2005) Mechanics and function in heart morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(2):373-381.
Abstract
For years, biomechanical engineers have studied the physical forces involved in morphogenesis of the heart. In a parallel stream of research, molecular and developmental biologists have sought to identify the molecular pathways responsible for embryonic heart development. Recently, several studies have shown that these two avenues of research should be integrated to explain how genes expressed in the heart regulate early heart function and affect physical morphogenetic steps, as well as to conversely show how early heart function affects the expression of genes required for morphogenesis. This review combines the perspectives of biomechanical engineering and developmental biology to lay out an integrated view of the role of mechanical forces in heart development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping