PUBLICATION
The zebrafish as a model system for assessing the reinforcing properties of drugs of abuse
- Authors
- Ninkovic, J., and Bally-Cuif, L.
- ID
- ZDB-PUB-060703-16
- Date
- 2006
- Source
- Methods (San Diego, Calif.) 39(3): 262-274 (Journal)
- Registered Authors
- Bally-Cuif, Laure, Ninkovic, Jovica
- Keywords
- Zebrafish, Addiction, Conditioned place preference (CPP), Aversion, Learning and memory, d-Amphetamine, Behavior
- MeSH Terms
-
- Animals
- Behavior, Addictive/genetics
- Conditioning, Psychological
- Dextroamphetamine/toxicity
- Disease Models, Animal*
- Illicit Drugs/toxicity
- Mutation
- Reinforcement, Psychology*
- Substance-Related Disorders/genetics*
- Toxicity Tests/instrumentation
- Toxicity Tests/methods
- Zebrafish/genetics*
- Zebrafish/physiology
- PubMed
- 16809048 Full text @ Methods
Citation
Ninkovic, J., and Bally-Cuif, L. (2006) The zebrafish as a model system for assessing the reinforcing properties of drugs of abuse. Methods (San Diego, Calif.). 39(3):262-274.
Abstract
Recent reports make use of the zebrafish to study complex behavior such as addiction, anxiety, or learning and memory. We have established reliable tests and appropriate controls to measure these behavioral parameters in the zebrafish adult. Our assays are robust enough to permit the detection of dominant mutations affecting drug-induced reward, and therefore can be used in forward genetic screens. We provide the reader with the technical details of these tests, as well as their appropriate and crucial, although often overlooked, control assays. In particular, our results make it possible to use the zebrafish as a promising model to identify new genetic components of the reward pathway, or other measurable behaviors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping