ZFIN ID: ZDB-PUB-060412-11
The chemokine SDF-1 regulates blastema formation during zebrafish fin regeneration
Dufourcq, P., and Vriz, S.
Date: 2006
Source: Development genes and evolution   216(10): 635-639 (Journal)
Registered Authors: Dufourcq, Pascale, Vriz, Sophie
Keywords: Regeneration, Progenitor cells, Chemokine, Sdf1, Cxcr4
MeSH Terms:
  • Animals
  • Chemokines, CXC/physiology*
  • In Situ Hybridization
  • Regeneration*
  • Zebrafish/physiology*
PubMed: 16586100 Full text @ Dev. Genes Evol.
The work presented in this study focuses on blastema formation in epimorphic regeneration. We describe the expression pattern of Sdf1a and Sdf1b (the chemokines stromal-cell-derived factor-1a and 1b) and their two receptors Cxcr4a and Cxcr4b during zebrafish fin regeneration. We demonstrate that Sdf1a/Cxcr4a plays a critical role in fin regeneration and more precisely in epidermal cell proliferation, an important process for blastema formation. In mammals, a single cxcr4 gene is involved both in chemotaxis and cell proliferation and survival; we discuss in this study a possible functional division of the two cxcr4 zebrafish genes.