PUBLICATION

The chemokine SDF-1 regulates blastema formation during zebrafish fin regeneration

Authors
Dufourcq, P., and Vriz, S.
ID
ZDB-PUB-060412-11
Date
2006
Source
Development genes and evolution   216(10): 635-639 (Journal)
Registered Authors
Dufourcq, Pascale, Vriz, Sophie
Keywords
Regeneration, Progenitor cells, Chemokine, Sdf1, Cxcr4
MeSH Terms
  • Animals
  • Chemokines, CXC/physiology*
  • In Situ Hybridization
  • Regeneration*
  • Zebrafish/physiology*
PubMed
16586100 Full text @ Dev. Genes Evol.
Abstract
The work presented in this study focuses on blastema formation in epimorphic regeneration. We describe the expression pattern of Sdf1a and Sdf1b (the chemokines stromal-cell-derived factor-1a and 1b) and their two receptors Cxcr4a and Cxcr4b during zebrafish fin regeneration. We demonstrate that Sdf1a/Cxcr4a plays a critical role in fin regeneration and more precisely in epidermal cell proliferation, an important process for blastema formation. In mammals, a single cxcr4 gene is involved both in chemotaxis and cell proliferation and survival; we discuss in this study a possible functional division of the two cxcr4 zebrafish genes.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes