PUBLICATION
No organ left behind: tales of gut development and evolution
- Authors
- Stainier, D.Y.
- ID
- ZDB-PUB-060216-11
- Date
- 2005
- Source
- Science (New York, N.Y.) 307(5717): 1902-1904 (Review)
- Registered Authors
- Stainier, Didier
- Keywords
- none
- MeSH Terms
-
- Mesoderm/physiology
- Animals
- Diet
- Humans
- Digestive System/embryology*
- Digestive System/microbiology
- Intestinal Mucosa/cytology
- Intestinal Mucosa/embryology
- Intestines/abnormalities
- Intestines/embryology*
- Intestines/microbiology
- Intestines/physiology
- Digestive System Physiological Phenomena
- Epigenesis, Genetic
- Digestive System Abnormalities
- Gene Expression Regulation, Developmental
- Morphogenesis
- Stem Cells/physiology
- Body Patterning
- Genes, Homeobox
- Endoderm/physiology
- Biological Evolution*
- Signal Transduction
- PubMed
- 15790841 Full text @ Science
Citation
Stainier, D.Y. (2005) No organ left behind: tales of gut development and evolution. Science (New York, N.Y.). 307(5717):1902-1904.
Abstract
The function of an organ is dependent on its cellular constituents as well as on their assembly into a cohesive unit. The developing gut faces unique challenges as one of the longest and largest organs in the body and also because it is constantly interfacing with external factors through the diet. Its location deep within the body has until recently hampered investigation into its formation. The patterning of the gut along its longitudinal, dorsoventral, left-right, and radial axes is one of the fascinating issues that pertain to the development, function, and homeostasis of this understudied organ.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping