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ZFIN ID: ZDB-PUB-060216-11
No organ left behind: tales of gut development and evolution
Stainier, D.Y.
Date: 2005
Source: Science (New York, N.Y.)   307(5717): 1902-1904 (Review)
Registered Authors: Stainier, Didier
Keywords: none
MeSH Terms:
  • Animals
  • Biological Evolution*
  • Body Patterning
  • Diet
  • Digestive System/embryology*
  • Digestive System/microbiology
  • Digestive System Abnormalities
  • Digestive System Physiological Phenomena
  • Endoderm/physiology
  • Epigenesis, Genetic
  • Gene Expression Regulation, Developmental
  • Genes, Homeobox
  • Humans
  • Intestinal Mucosa/cytology
  • Intestinal Mucosa/embryology
  • Intestines/abnormalities
  • Intestines/embryology*
  • Intestines/microbiology
  • Intestines/physiology
  • Mesoderm/physiology
  • Morphogenesis
  • Signal Transduction
  • Stem Cells/physiology
PubMed: 15790841 Full text @ Science
The function of an organ is dependent on its cellular constituents as well as on their assembly into a cohesive unit. The developing gut faces unique challenges as one of the longest and largest organs in the body and also because it is constantly interfacing with external factors through the diet. Its location deep within the body has until recently hampered investigation into its formation. The patterning of the gut along its longitudinal, dorsoventral, left-right, and radial axes is one of the fascinating issues that pertain to the development, function, and homeostasis of this understudied organ.