Molecular cloning and expression of two small leucine-rich proteoglycan (SLRP) genes, dspg3l and optcl, in zebrafish
- Zhou, W., Shirabe, K., and Kuwada, J.Y.
- Gene expression patterns : GEP 6(5): 482-488 (Journal)
- Registered Authors
- Kuwada, John, Zhou, Weibin
- Zebrafish, Leucine-rich repeat, LRR, Proteoglycan, SLRP, Epiphycan, PG-Lb, Opticin, Dermatan sulphate proteoglycan 3, Dspg3, Cartilage, Floor plate, Spinal cord, Midbrain hindbrain boundary, MHB, Otic vesicle, Optic vesicle, Lens, Somite
- MeSH Terms
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA Primers
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Zebrafish Proteins/chemistry
- Zebrafish Proteins/genetics*
- 16458084 Full text @ Gene Expr. Patterns
Zhou, W., Shirabe, K., and Kuwada, J.Y. (2006) Molecular cloning and expression of two small leucine-rich proteoglycan (SLRP) genes, dspg3l and optcl, in zebrafish. Gene expression patterns : GEP. 6(5):482-488.
Epiphycan (DSPG3) and opticin are two class III small leucine-rich proteoglycans (SLRP). We isolated two zebrafish cDNAs, dspg3l and optcl, that encode proteins homologous to epiphycan and opticin in other vertebrates. Like epiphycans in other species, dspg3l is exclusively expressed in the developing notochord and cartilage. optcl is expressed transiently in the developing nervous system, eyes and somites much like opticin. The zebrafish dspg3l and optcl genes are located in linkage group 4 and 11, respectively. The genomic locations for both genes in zebrafish are syntenic with the genomic locations of dspg3 and opticin (optc) in human and mouse. Synteny and the expression patterns of these genes suggest that the dspg3l and optcl are the orthologs to the mammalian dspg3 and optc genes, respectively.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes