ZFIN ID: ZDB-PUB-060210-8
Molecular cloning and expression of two small leucine-rich proteoglycan (SLRP) genes, dspg3l and optcl, in zebrafish
Zhou, W., Shirabe, K., and Kuwada, J.Y.
Date: 2006
Source: Gene expression patterns : GEP   6(5): 482-488 (Journal)
Registered Authors: Kuwada, John, Zhou, Weibin
Keywords: Zebrafish, Leucine-rich repeat, LRR, Proteoglycan, SLRP, Epiphycan, PG-Lb, Opticin, Dermatan sulphate proteoglycan 3, Dspg3, Cartilage, Floor plate, Spinal cord, Midbrain hindbrain boundary, MHB, Otic vesicle, Optic vesicle, Lens, Somite
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA Primers
  • Humans
  • Molecular Sequence Data
  • Proteoglycans/chemistry
  • Proteoglycans/genetics*
  • Sequence Homology, Amino Acid
  • Zebrafish/genetics*
  • Zebrafish Proteins/chemistry
  • Zebrafish Proteins/genetics*
PubMed: 16458084 Full text @ Gene Expr. Patterns
Epiphycan (DSPG3) and opticin are two class III small leucine-rich proteoglycans (SLRP). We isolated two zebrafish cDNAs, dspg3l and optcl, that encode proteins homologous to epiphycan and opticin in other vertebrates. Like epiphycans in other species, dspg3l is exclusively expressed in the developing notochord and cartilage. optcl is expressed transiently in the developing nervous system, eyes and somites much like opticin. The zebrafish dspg3l and optcl genes are located in linkage group 4 and 11, respectively. The genomic locations for both genes in zebrafish are syntenic with the genomic locations of dspg3 and opticin (optc) in human and mouse. Synteny and the expression patterns of these genes suggest that the dspg3l and optcl are the orthologs to the mammalian dspg3 and optc genes, respectively.