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ZFIN ID: ZDB-PUB-051101-17
cadherin-6 Message expression in the nervous system of developing zebrafish
Liu, Q., Liu, B., Wilson, A.L., and Rostedt, J.
Date: 2006
Source: Developmental dynamics : an official publication of the American Association of Anatomists 235(1): 272-278 (Journal)
Registered Authors: Liu, Qin
Keywords: zebrafish, development, cell adhesion molecules, brain, cranial ganglia, lateral line system
MeSH Terms:
  • Animals
  • Cadherins/biosynthesis*
  • Cadherins/genetics*
  • Central Nervous System/chemistry
  • Central Nervous System/metabolism*
  • Peripheral Nervous System/chemistry
  • Peripheral Nervous System/metabolism*
  • RNA, Messenger/biosynthesis*
  • RNA, Messenger/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Zebrafish/metabolism
PubMed: 16258934 Full text @ Dev. Dyn.
Cadherins are cell surface adhesion molecules that play important roles in development of a variety of tissues including the nervous system. In this study, we analyzed expression pattern of cadherin-6, a member of the type II cadherin subfamily, in the embryonic zebrafish nervous system using in situ hybridization methods. cadherin-6 message is first expressed by the neural keel, then by restricted regions in the brain and spinal cord. cadherin-6 expression in the brain transiently delineates specific brain regions. In the peripheral nervous system, cadherin-6 message is expressed by the neurogenic placodes and the dorsal root ganglia. As development proceeds, cadherin-6 expression domain and/or expression levels increased in the embryonic nervous system. Our results show that cadherin-6 expression in the zebrafish developing nervous system is both spatially and temporally regulated, implicating a role for cadherin-6 in the formation of these nervous structures.