PUBLICATION

The "Fish Specific" Hox Cluster Duplication is Coincident with the Origin of Teleosts

Authors
Crow, K.D., Stadler, P.F., Lynch, V.J., Amemiya, C., and Wagner, G.P.
ID
ZDB-PUB-050920-5
Date
2006
Source
Mol. Biol. Evol.   23(1): 121-136 (Journal)
Registered Authors
Amemiya, Chris
Keywords
Hox cluster, genome duplication, ray-finned fishes, Darwinian selection
MeSH Terms
  • Animals
  • Base Sequence
  • DNA Primers
  • Evolution, Molecular*
  • Fishes/genetics*
  • Gene Duplication*
  • Genes, Homeobox/genetics*
  • Genetic Speciation*
  • Likelihood Functions
  • Models, Genetic
  • Molecular Sequence Data
  • Phylogeny*
  • Sequence Analysis, DNA
PubMed
16162861 Full text @ Mol. Biol. Evol.
Abstract
The Hox gene complement of zebrafish, medaka, and fugu differs from that of other gnathostome vertebrates. These fishes have seven to eight Hox clusters compared to the four Hox clusters described in sarcopterygians and shark. The clusters in different teleost lineages are orthologous, implying that a "fish specific" Hox cluster duplication has occurred in the stem lineage leading to the most recent common ancestor of zebrafish and fugu. The timing of this event, however, is unknown. To address this question, we sequenced four Hox genes from taxa representing basal actinopterygian and teleost lineages, and compared them to known sequences from shark, coelacanth, zebrafish and other teleosts. The resulting gene genealogies suggest that the "fish specific" Hox cluster duplication occurred coincident with the origin of crown group teleosts. In addition, we obtained evidence for an independent Hox cluster duplication in the sturgeon lineage (Acipenseriformes). Finally, results from HoxA11 suggest that duplicated Hox genes have experienced diversifying selection immediately after the duplication event. Taken together, these results support the notion that the duplicated Hox genes of teleosts were causally relevant to adaptive evolution during the initial teleost radiation.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes