|ZFIN ID: ZDB-PUB-050607-3|
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Hedgehog signalling and the specification of muscle cell identity in the Zebrafish embryo
Ingham, P.W., and Kim, H.R.
|Source:||Experimental cell research 306(2): 336-342 (Review)|
|Registered Authors:||Ingham, Philip, Kim, Rosemary|
|Keywords:||Hedgehog signalling; Zebrafish; Muscle cell; Blimp1; Slow twitch fibre|
|PubMed:||15925589 Full text @ Exp. Cell Res.|
Ingham, P.W., and Kim, H.R. (2005) Hedgehog signalling and the specification of muscle cell identity in the Zebrafish embryo. Experimental cell research. 306(2):336-342.
ABSTRACTSignalling by members of the Hedgehog family of secreted proteins plays a central role in the development of many animal species. In the zebrafish embryo, the specification of myoblast fates is controlled by Hedgehog signals emanating from axial midline structures. Distinct muscle cell identities are induced by varying levels of signalling activity. The SET domain transcription factor, Blimp1, is a key target of Hedgehog signalling in this process.