|ZFIN ID: ZDB-PUB-050523-9|
Zebrafish Hairy/Enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites
Kawamura, A., Koshida, S., Hijikata, H., Sakaguchi, T., Kondoh, H., and Takada, S.
|Source:||Genes & Development 19(10): 1156-1161 (Journal)|
|Registered Authors:||Kawamura, Akinori, Kondoh, Hisato, Koshida, Sumito, Sakaguchi, Takuya, Takada, Shinji|
|Keywords:||Somite segmentation; FGF signaling; cyclic gene expression; hairy/Espl; negative feedback loop; zebrafish|
|PubMed:||15905406 Full text @ Genes & Dev.|
Kawamura, A., Koshida, S., Hijikata, H., Sakaguchi, T., Kondoh, H., and Takada, S. (2005) Zebrafish Hairy/Enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites. Genes & Development. 19(10):1156-1161.
ABSTRACTNotch and fibroblast growth factor (FGF) signaling pathways have been implicated in the establishment of proper periodicity of vertebrate somites. Here, we show evidence that a Hes6-related hairy/Enhancer of split-related gene, her13.2, links FGF signaling to the Notch-regulated oscillation machinery in zebrafish. Expression of her13.2 is induced by FGF-soaked beads and decreased by an FGF signaling inhibitor. her13.2 is required for periodic repression of the Notch-regulated genes her1 and her7, and for proper somite segmentation. Furthermore, Her13.2 augments autorepression of her1 in association with Her1 protein. Therefore, FGF signaling appears to maintain the oscillation machinery by supplying a binding partner, Her13.2, for Her1.