|ZFIN ID: ZDB-PUB-050523-11|
Characterization and expression pattern of two zebrafish atf7 genes
Zhao, C., Qi, J., and Meng, A.
|Source:||Developmental dynamics : an official publication of the American Association of Anatomists 233(3): 1157-1162 (Journal)|
|Registered Authors:||Meng, Anming, Zhao, Chengtian|
|Keywords:||zebrafish; mammalian; embryo; notochord; expression pattern; activating transcription factor; ATF7|
|PubMed:||15906372 Full text @ Dev. Dyn.|
Zhao, C., Qi, J., and Meng, A. (2005) Characterization and expression pattern of two zebrafish atf7 genes. Developmental dynamics : an official publication of the American Association of Anatomists. 233(3):1157-1162.
ABSTRACTMembers of the ATF/CREB (activating transcription factor/cAMP-responsive element binding protein) transcription factor family play diverse roles in controlling cell proliferation, apoptosis, and oncogenesis, as well as in embryonic development of vertebrates. We identified two zebrafish orthologs of human ATF7 gene: atf7a and atf7b. Whole-mount in situ hybridization shows that zebrafish atf7a is first expressed in the notochord precursors at 80% epiboly stage and then in the developing notochord during segmentation. The expression of atf7a is positively regulated by ntl, flh, and spr2, which are involved in development of the notochord. In contrast, atf7b is maternally expressed and during embryogenesis its mRNA is ubiquitously distributed, showing an expression pattern similar to that of mammalian Atf7. Developmental Dynamics, 2005. (c) 2005 Wiley-Liss, Inc.