PUBLICATION
Comparative genomics on Norrie disease gene
- Authors
- Katoh, M., and Katoh, M.
- ID
- ZDB-PUB-050413-2
- Date
- 2005
- Source
- International journal of molecular medicine 15(5): 885-889 (Journal)
- Registered Authors
- Katoh, Masaru
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- Chickens
- Computational Biology
- Exons
- Eye Proteins/genetics*
- Humans
- Intracellular Signaling Peptides and Proteins/genetics*
- Molecular Sequence Data
- Nerve Tissue Proteins/genetics*
- Promoter Regions, Genetic
- Rats
- Sequence Alignment
- Species Specificity
- Zebrafish Proteins/genetics*
- PubMed
- 15806314 Full text @ Int. J. Mol. Med.
Citation
Katoh, M., and Katoh, M. (2005) Comparative genomics on Norrie disease gene. International journal of molecular medicine. 15(5):885-889.
Abstract
DAND1 (NBL1), DAND2 (CKTSF1B1 or GREM1 or GREMLIN), DAND3 (CKTSF1B2 or GREM2 or PRDC), DAND4 (CER1), DAND5 (CKTSF1B3 or GREM3 or DANTE), MUC2, MUC5AC, MUC5B, MUC6, MUC19, WISP1, WISP2, WISP3, VWF, NOV and Norrie disease (NDP or NORRIN) genes encode proteins with cysteine knot domain. Cysteine-knot superfamily proteins regulate ligand-receptor interactions for a variety of signaling pathways implicated in embryogenesis, homeostasis, and carcinogenesis. Although Ndp is unrelated to Wnt family members, Ndp is claimed to function as a ligand for Fzd4. Here, we identified and characterized rat Ndp, cow Ndp, chicken ndp and zebrafish ndp genes by using bioinformatics. Rat Ndp gene, consisting of three exons, was located within AC105563.4 genome sequence. Cow Ndp and chicken ndp complete CDS were derived from CB467544.1 EST and BX932859.2 cDNA, respectively. Zebrafish ndp gene was located within BX572627.5 genome sequence. Rat Ndp (131 aa) was a secreted protein with C-terminal cysteine knot-like (CTCK) domain. Rat Ndp showed 100, 96.9, 95.4, 87.8 and 66.4 total-amino-acid identity with mouse Ndp, cow Ndp, human NDP, chicken ndp and zebrafish ndp, respectively. Exon-intron structure of mammalian Ndp orthologs was well conserved. FOXA2, CUTL1 (CCAAT displacement protein), LMO2, CEBPA (C/EBPalpha)-binding sites and triple POU2F1 (OCT1)-binding sites were conserved among promoters of mammalian Ndp orthologs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping