ZFIN ID: ZDB-PUB-041111-21
gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafish
Cheesman, S.E., and Eisen, J.S.
Date: 2004
Source: Gene Expression Patterns 5(1): 107-112 (Journal)
Registered Authors: Cheesman, Sarah, Eisen, Judith S.
Keywords: Danio rerio; CNS; Mesencephalon; msxb; Diencephalon; Pax2; shh; Rhombomere 3
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Homeodomain Proteins/genetics*
  • Homeodomain Proteins/metabolism
  • Hypothalamus/embryology*
  • Hypothalamus/metabolism
  • Molecular Sequence Data
  • Spinal Cord/embryology*
  • Spinal Cord/metabolism
  • Zebrafish/embryology
  • Zebrafish/genetics*
  • Zebrafish/metabolism
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 15533825 Full text @ Gene Expr. Patterns
We have cloned and characterized the expression of zebrafish genetic screen homeobox 1 (gsh1). Early expression is confined to hindbrain rhombomeres; by mid-somitogenesis gsh1 is expressed in precise domains within the mesencephalon and diencephalon, as well as in intermediate spinal cord. Double-label experiments revealed that the diencephalic domain is coincident with hypothalamus and that spinal cord expression is in a region that generates interneurons. These data suggest gsh1 may play a role in patterning cell types generated in these domains.