PUBLICATION

Using zebrafish to study the complex genetics of glaucoma

Authors
McMahon, C., Semina, E.V., and Link, B.A.
ID
ZDB-PUB-041111-11
Date
2004
Source
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP   138(3): 343-350 (Review)
Registered Authors
Link, Brian, McMahon, Carrie
Keywords
Anterior segment; Complex disease; Eye; FoxC1; Glaucoma; Lmx1b; Pitx; Zebrafish
MeSH Terms
  • Animals
  • Fish Diseases/genetics
  • Fish Diseases/metabolism
  • Glaucoma/genetics*
  • Glaucoma/metabolism
  • Glaucoma/pathology
  • Homeodomain Proteins/genetics
  • Homeodomain Proteins/metabolism
  • Humans
  • LIM-Homeodomain Proteins
  • Transcription Factors
  • Zebrafish/genetics*
  • Zebrafish/metabolism
PubMed
15533792 Full text @ Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Abstract
The overall goal of this review is to highlight the power of zebrafish as a model system for studying complex diseases which involve multiple genetic loci. We are interested in identifying and characterizing genes implicated in the blinding condition of glaucoma. Glaucoma is a complex disease that often involves multiple genetic loci. Most disease causing and modifying genes for glaucoma remain unidentified. However, several genes that regulate various aspects of ocular development have been shown to associate with glaucoma. With zebrafish, forward and reverse genetic approaches can be combined in order to identify critical genetic interactions required for normal and pathological events in the development and maintenance of the eye.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes