PUBLICATION
Harnessing zebrafish for the study of white blood cell development and its perturbation
- Authors
- Onnebo, S.M., Yoong, S.H, and Ward, A.C.
- ID
- ZDB-PUB-040908-15
- Date
- 2004
- Source
- Experimental hematology 32(9): 789-796 (Journal)
- Registered Authors
- Ward, Alister
- Keywords
- none
- MeSH Terms
-
- Animals
- Leukemia/etiology
- Leukocytes/physiology*
- Models, Animal
- Mutation
- Zebrafish/blood*
- Zebrafish/genetics
- PubMed
- 15345279 Full text @ Exp. Hematol.
Citation
Onnebo, S.M., Yoong, S.H, and Ward, A.C. (2004) Harnessing zebrafish for the study of white blood cell development and its perturbation. Experimental hematology. 32(9):789-796.
Abstract
Considerable progress has been made in understanding the molecular basis of normal white blood cell development and its perturbation in disease through the use of clinical studies and traditional animal and cell line models. Despite this, however, many questions are still being answered and white blood cell disorders, including leukemia and lymphoma, remain a significant health problem. The zebrafish (Danio rerio) has emerged as a powerful alternative vertebrate model for the study of development and disease. We review the recent application of zebrafish to the study of white blood cell development and its disruption, particularly leukemogenesis. Such studies have highlighted the overall conservation of these processes throughout vertebrates, and establish zebrafish as a useful experimental model. This organism is now poised to make an important contribution to our understanding of the underlying genetic control of white blood cell development and its disruption, as well as the identification of new therapeutic agents.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping