|ZFIN ID: ZDB-PUB-040609-5|
Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish
Bae, Y.K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., and Hibi, M.
|Source:||Gene expression patterns : GEP 4(4): 481-486 (Journal)|
|Registered Authors:||Bae, Young Ki, Hibi, Masahiko, Hirata, Tsutomu, Muraoka, Osamu, Nojima, Hideaki, Shimizu, Takashi, Yabe, Taijirou|
|Keywords:||Homeobox, Neuroectoderm, Floor plate, Zebrafish|
|PubMed:||15183316 Full text @ Gene Expr. Patterns|
Bae, Y.K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., and Hibi, M. (2004) Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Gene expression patterns : GEP. 4(4):481-486.
ABSTRACTsax1/nkx1.2 and sax2/nkx1.1 are members of the evolutionally conserved NK-1 homeobox gene family. sax1/nkx1.2 is reported to be expressed in the central nervous system during early and late neurogenesis in the chick and mouse, but the expression of sax2/nkx1.1 has not been reported. We isolated zebrafish cDNAs for sax1/nkx1.2 and sax2/nkx1.1 and examined their expression. In zebrafish, unlike chick and mouse, sax1/nkx1.2 was expressed in the prospective medial floor plate from the mid-gastrula period and was dependent on Nodal signaling. From the early segmentation period, sax1/nkx1.2 was also expressed in the posterior neuroectoderm. sax2/nkx1.1 was expressed in the prospective extraocular muscles, mesencephalic neurons residing along the tract of the posterior commissure, ventral neurons in the hindbrain, and interneurons in the spinal cord.