|ZFIN ID: ZDB-PUB-040429-5|
On the relevance of genotoxicity for fish populations I: effects of a model genotoxicant on zebrafish (Danio rerio) in a complete life-cycle test
Diekmann, M., Hultsch, V., and Nagel, R.
|Source:||Aquatic toxicology (Amsterdam, Netherlands) 68(1): 13-26 (Journal)|
|Registered Authors:||Nagel, Roland|
|Keywords:||Zebrafish, Life-cycle test, Population, 4-Nitroquinoline-1-oxide|
|PubMed:||15110466 Full text @ Aquat. Toxicol.|
Diekmann, M., Hultsch, V., and Nagel, R. (2004) On the relevance of genotoxicity for fish populations I: effects of a model genotoxicant on zebrafish (Danio rerio) in a complete life-cycle test. Aquatic toxicology (Amsterdam, Netherlands). 68(1):13-26.
ABSTRACTGenotoxicity may be detected in surface waters by means of various genotoxicity assays. In order to enable an ecotoxicological assessment of the consequences of such genotoxic potential for fish populations, a complete life-cycle test with zebrafish (Danio rerio) and the model genotoxicant 4-nitroquinoline-1-oxide (NQO) was conducted. Zebrafish (f(1)) were continuously exposed to NQO (i.e. 0.1, 0.3, 1.1, 2.9, and 14.6microg/l, respectively) from fertilised eggs until sexual maturity. In addition to reproduction studies in the f(1)-generation, f(2)-fish were exposed to NQO during the first 6 weeks of development. Up to 2.9microg/l NQO, fish did not display differences in survival and growth [Formula: see text]. A NQO concentration of 14.6microg/l, however, was lethal. Female fish exposed to all NQO concentrations up to 2.9microg/l displayed a significant reduction in egg production [Formula: see text]. A mathematical simulation revealed that exposure to weak concentrations of NQO is leading to an elevated extinction risk.
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