|ZFIN ID: ZDB-PUB-040427-2|
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Cadherin-2 function in the cranial ganglia and lateral line system of developing zebrafish
Kerstetter, A.E., Azodi, E., Marrs, J.A., and Liu, Q.
|Source:||Developmental dynamics : an official publication of the American Association of Anatomists 230(1): 137-143 (Journal)|
|Registered Authors:||Liu, Qin, Marrs, James A.|
|Keywords:||zebrafish, development, neuromasts, cell adhesion molecules, cranial nerves|
|PubMed:||15108318 Full text @ Dev. Dyn.|
Kerstetter, A.E., Azodi, E., Marrs, J.A., and Liu, Q. (2004) Cadherin-2 function in the cranial ganglia and lateral line system of developing zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 230(1):137-143.
ABSTRACTCadherins are cell surface molecules that mediate cell-cell adhesion through homophilic interactions. Cadherin-2 (also called N-cadherin), a member of classic cadherin subfamily, has been shown to play important roles in development of a variety of tissues and organs, including the nervous system. We recently reported that cadherin-2 was strongly expressed by the majority of cranial ganglia and lateral line system of developing zebrafish. To gain insight into cadherin-2 role in the formation of these structures, we have used several markers to analyze zebrafish embryos injected with a specific cadherin-2 antisense morpholino oligonucleotide (cdh2MO). We find that development of several cranial ganglia, including the trigeminal, facial, and vagal ganglia, and the lateral line ganglia and neuromasts of the cdh2MO-injected embryos are severely disrupted. These phenotypes were confirmed by analyzing a cadherin-2 mutant, glass onion. Our results suggest that cadherin-2 function is crucial for the normal formation of the zebrafish lateral line system and a subset of cranial ganglia. Developmental Dynamics 230:137-143, 2004. Copyright 2004 Wiley-Liss, Inc.