ZFIN ID: ZDB-PUB-040427-2 |
Cadherin-2 function in the cranial ganglia and lateral line system of developing zebrafish
Kerstetter, A.E., Azodi, E., Marrs, J.A., and Liu, Q.
Date: | 2004 |
---|---|
Source: | Developmental dynamics : an official publication of the American Association of Anatomists 230(1): 137-143 (Journal) |
Registered Authors: | Liu, Qin, Marrs, James A. |
Keywords: | zebrafish, development, neuromasts, cell adhesion molecules, cranial nerves |
MeSH Terms: |
|
PubMed: | 15108318 Full text @ Dev. Dyn. |
Citation
Kerstetter, A.E., Azodi, E., Marrs, J.A., and Liu, Q. (2004) Cadherin-2 function in the cranial ganglia and lateral line system of developing zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 230(1):137-143.
ABSTRACT
Cadherins are cell surface molecules that mediate cell-cell adhesion through homophilic interactions. Cadherin-2 (also called N-cadherin), a member of classic cadherin subfamily, has been shown to play important roles in development of a variety of tissues and organs, including the nervous system. We recently reported that cadherin-2 was strongly expressed by the majority of cranial ganglia and lateral line system of developing zebrafish. To gain insight into cadherin-2 role in the formation of these structures, we have used several markers to analyze zebrafish embryos injected with a specific cadherin-2 antisense morpholino oligonucleotide (cdh2MO). We find that development of several cranial ganglia, including the trigeminal, facial, and vagal ganglia, and the lateral line ganglia and neuromasts of the cdh2MO-injected embryos are severely disrupted. These phenotypes were confirmed by analyzing a cadherin-2 mutant, glass onion. Our results suggest that cadherin-2 function is crucial for the normal formation of the zebrafish lateral line system and a subset of cranial ganglia. Developmental Dynamics 230:137-143, 2004. Copyright 2004 Wiley-Liss, Inc.
ADDITIONAL INFORMATION
- Genes / Markers (2)
- Morpholino (1)
- Antibodies (2)
- Mutations and Transgenics (1)
- Fish (1)