ZFIN ID: ZDB-PUB-031103-17
Expression and phylogenetic analyses of three zebrafish FoxI class genes
Solomon, K.S., Logsdon, Jr., J.M., and Fritz, A.
Date: 2003
Source: Developmental dynamics : an official publication of the American Association of Anatomists   228(3): 301-307 (Journal)
Registered Authors: Solomon, Keely
Keywords: Forkhead, Danio rerio, foxi1, transcription factor
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Conserved Sequence
  • Embryo, Nonmammalian/physiology
  • Gene Expression Regulation, Developmental/genetics*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Morphogenesis
  • Multigene Family
  • Phylogeny*
  • RNA-Binding Proteins/chemistry
  • RNA-Binding Proteins/genetics*
  • Rats
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Zebrafish/classification
  • Zebrafish/embryology
  • Zebrafish/genetics*
  • Zebrafish Proteins/chemistry
  • Zebrafish Proteins/genetics*
PubMed: 14579370 Full text @ Dev. Dyn.
We have identified three novel members of the zebrafish forkhead class I gene family, which we have named foxi2, foxi3a, and foxi3b. We have reported previously the identification of zebrafish foxi1, which is required for otic placode and jaw development. Expression analysis shows that foxi2 is expressed within the chordamesoderm during early somitogenesis and the retina and pharyngeal arches during later stages. The foxi3a and foxi3b genes likely represent a recently duplicated pair, and they are similarly expressed in epidermal mucous cells throughout embryogenesis and early larval stages. None of these newly identified FoxI genes are expressed in otic precursor cells and, therefore, are unlikely to share functional overlap with foxi1 in the development of the inner ear. In addition to these zebrafish FoxI paralogs, we have identified 16 new FoxI sequences in species ranging from Ciona intestinalis to Homo sapiens. We present an extensive phylogenetic analysis of the FoxI class that includes these new sequences together with those previously reported. This analysis supports the existence of three subfamilies within the FoxI class, each containing at least one zebrafish member.