| ZFIN ID: ZDB-PUB-031009-4 |
The microRNA-producing enzyme Dicer1 is essential for zebrafish development
Wienholds, E., Koudijs, M.J., van Eeden, F.J., Cuppen, E., and Plasterk, R.H.
| Date: | 2003 |
|---|---|
| Source: | Nature Genetics 35(3): 217-218 (Journal) |
| Registered Authors: | Cuppen, Edwin, Plasterk, Ronald H.A., van Eeden, Freek, Wienholds, Erno |
| Keywords: | none |
| MeSH Terms: |
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| PubMed: | 14528306 Full text @ Nat. Genet. |
Citation
Wienholds, E., Koudijs, M.J., van Eeden, F.J., Cuppen, E., and Plasterk, R.H. (2003) The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nature Genetics. 35(3):217-218.
ABSTRACT
MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.
ADDITIONAL INFORMATION
- Genes / Markers (2)
- Morpholino (2)
- Mutations and Transgenics (3)
- Fish (3)