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ZFIN ID: ZDB-PUB-030919-6
Cadherin-1, -2 and -4 expression in the cranial ganglia and lateral line system of developing zebrafish
Liu, Q., Ensign, R.D., and Azodi, E.
Date: 2003
Source: Gene expression patterns : GEP 3(5): 653-658 (Journal)
Registered Authors: Liu, Qin
Keywords: zebrafish; development; neuromasts; cell adhesion molecules; cranial nerves
MeSH Terms:
  • Animals
  • Base Sequence
  • Cadherins/metabolism*
  • Cranial Nerves/metabolism*
  • Embryo, Nonmammalian
  • Ganglia, Sensory/metabolism*
  • Gene Expression Regulation, Developmental
  • Molecular Sequence Data
  • Nervous System Physiological Phenomena
  • Zebrafish/growth & development*
  • Zebrafish/metabolism
PubMed: 12972001 Full text @ Gene Expr. Patterns
ABSTRACT
Cadherins are cell adhesion molecules that play important roles in development of a variety of tissues and organs including the nervous system. In this study we analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system using in situ hybridization and immunohistochemical methods. All three cadherins exhibit distinct spatiotemporal patterns of expression during cranial ganglia and lateral line system development. cadherin-1 message was detected in the trigeminal and facial ganglia, in the lateral line ganglia, and in most of neuromasts in the lateral lines. Cadherin-2 mRNA and protein were expressed by the majority of the cranial ganglia and lateral line system. Both cadherins were found in embryos younger than 24hours post fertilization as well as in 2-3-day old embryos and larvae. In contrast, cadherin-4 mRNA and protein expression was detected in embryos older than 30hours post fertilization and limited to the trigeminal, statoacoustic, and vagal cranial ganglia, and the lateral line ganglia of older embryos and larvae.
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