PUBLICATION
Hey genes in cardiovascular development
- Authors
- Fischer, A. and Gessler, M.
- ID
- ZDB-PUB-030826-16
- Date
- 2003
- Source
- Trends Cardiovasc. 13(6): 221-226 (Review)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cardiovascular System/embryology*
- Gene Expression
- Genes
- Helix-Loop-Helix Motifs*/genetics
- Humans
- Membrane Proteins/metabolism
- Proteins/genetics
- Receptors, Notch
- Signal Transduction
- Transcription Factors/chemistry
- Transcription Factors/genetics*
- Transcription Factors/physiology
- Zebrafish Proteins*
- PubMed
- 12922017 Full text @ Trends Cardiovasc.
Citation
Fischer, A. and Gessler, M. (2003) Hey genes in cardiovascular development. Trends Cardiovasc.. 13(6):221-226.
Abstract
Hey genes encode a small family of basic helix-loop-helix (bHLH) transcription factors that are related to the Drosophila hairy and Enhancer-of-split genes. They belong to the still-limited number of direct targets of the Notch signaling pathway and are thus candidate molecules to effect critical developmental decisions like lateral inhibition, boundary formation, and inductive processes in numerous tissues. Human inherited mutations such as cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukencephalopathy and Alagille syndrome, as well as several mouse models, have highlighted the role of Notch signals in cardiovascular development and maintenance. Functional analyses in both mouse and zebrafish now have shown that Hey genes appear to be the most prominent transmitters for such signals to shape the cardiovascular system during development and perhaps also in later life.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping