ZFIN ID: ZDB-PUB-030716-19
Leaning to the left: laterality in the zebrafish forebrain
Halpern, M.E., Liang, J.O., and Gamse, J.T.
Date: 2003
Source: Trends in neurosciences 26(6): 308-313 (Journal)
Registered Authors: Gamse, Josh, Halpern, Marnie E., Liang, Jennifer
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning/genetics*
  • Body Patterning/physiology
  • Diencephalon/growth & development
  • Diencephalon/metabolism
  • Epithalamus/growth & development*
  • Epithalamus/metabolism
  • Functional Laterality/genetics
  • Functional Laterality/physiology*
  • Gene Expression Regulation, Developmental/physiology
  • Learning/physiology
  • Nodal Protein
  • Organogenesis/genetics
  • Organogenesis/physiology
  • Signal Transduction/genetics
  • Signal Transduction/physiology
  • Transforming Growth Factor beta/genetics
  • Zebrafish/genetics
  • Zebrafish/growth & development*
PubMed: 12798600 Full text @ Trends Neurosci.
How the brain becomes lateralized is poorly understood. By contrast, much is known about molecular cues that specify the left-right axis of the body, fashioning the asymmetric morphology and positioning of the visceral organs. In zebrafish, the Nodal signaling pathway functions in visceral asymmetry and also in the embryonic brain, to bias laterality of the epithalamus. Formation of an asymmetric pineal complex differentially influences adjacent diencephalic nuclei, the left and right habenulae, which acquire distinctive molecular and cellular features. Results from the genetically tractable zebrafish system provide a promising entry point for exploring how left-right biases are established and propagated in the developing vertebrate brain.