|ZFIN ID: ZDB-PUB-030115-10|
The zebrafish as a tool for understanding the biology of visual disorders
Goldsmith, P. and Harris, W.A.
|Source:||Seminars in cell & developmental biology 14(1): 11-18 (Review)|
|Registered Authors:||Harris, William A.|
|Keywords:||Disease; Retina; Retinal; Vision; Zebrafish|
|PubMed:||12524002 Full text @ Sem. Cell Dev. Biol.|
Goldsmith, P. and Harris, W.A. (2003) The zebrafish as a tool for understanding the biology of visual disorders. Seminars in cell & developmental biology. 14(1):11-18.
ABSTRACTRetinal degenerations are the commonest cause of blindness in the Western world, affecting 5% of the population, yet remain largely untreatable. A better understanding of the mechanisms of disease is needed. Zebrafish fill a gap in the current repertoire of models, offering genetic tractability in a vertebrate. Their retina has many similarities with a human retina. Importantly, unlike rodents, they have rich colour vision, offering the potential to model the macular degenerations. A variety of physiological assays, genetic manipulations and histological tools have been developed and useful models of human disease created.
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