|ZFIN ID: ZDB-PUB-021106-1|
Inhibitory interactions controlling organizer activity in fish
Peyriéras, N., Lu, Y., Renucci, A., Lemarchandel, V., and Rosa, F.
|Source:||Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie 319(12): 1107-1112 (Journal)|
|Registered Authors:||Lemarchandel, Valerie, Renucci, Armand, Rosa, Frederic|
Peyriéras, N., Lu, Y., Renucci, A., Lemarchandel, V., and Rosa, F. (1996) Inhibitory interactions controlling organizer activity in fish. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 319(12):1107-1112.
ABSTRACTAn experimental system allowing the observation of 2 active organizing centers during zebrafish development is described. It was achieved by injection into a single marginal cell at the 16-cell stage of TARAM-A-D mRNA. TARAM-A-D was previously described as the mutated constitutive form of a type I receptor for transforming growth factor beta. In 80% of the injected embryos, 2 distinct organizers were observed at the onset of gastrulation. At the end of gastrulation, these embryos showed duplicated axial structures. Nevertheless, only 25% of the injected embryos displayed a recognizable axis duplication after 1 day of development. This paradox is taken as an evidence for suppressive effects exerted in a reciprocal manner when more than 1 organizing center is present.
- Genes / Markers (3)