|ZFIN ID: ZDB-PUB-021017-71|
Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling
Houart, C., Caneparo, L., Heisenberg, C.P., Barth, K.A., Take-uchi, M., and Wilson, S.W.
|Source:||Neuron 35(2): 255-265 (Journal)|
|Registered Authors:||Barth, Anukampa, Caneparo, Luca, Heisenberg, Carl-Philipp, Houart, Corinne, Take-uchi, Masaya, Wilson, Steve|
|PubMed:||12160744 Full text @ Neuron|
Houart, C., Caneparo, L., Heisenberg, C.P., Barth, K.A., Take-uchi, M., and Wilson, S.W. (2002) Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 35(2):255-265.
ABSTRACTCells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tlc, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tlc. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.