PUBLICATION

A microtubule array precedes the formation of the cleavage furrow during the first two-cell division cycles in zebrafish embryos

Authors: Lee, K.W., Webb, S.E., Ho, S.M., Wong, C.H., and Miller, A.L.
ID: ZDB-PUB-021017-53
Date: 2002
Source: Developmental Biology 247(2): 465-466 (Abstract)
Registered Authors: Lee, Karen W., Miller, Andrew L., Webb, Sarah E.
Keywords: none
MeSH Terms: none
PubMed: none

Abstract

It has been clearly established that microtubules play a crucial role during cell division. Until recently, their functional role was restricted to the formation of the mitotic spindle and the astral array (1). However, recent evidence suggests that they might have additional roles in furrow formation following karyokinesis. It was recently reported that in zebrafish an array of parallel microtubules is present on either side of the cleavage furrow during furrow deepening (b). It was suggested that this array might function as a transportation mechanism to bring new membrane components to the expanding daughter cell membranes. Here we present new data showing the presence of a cytokinetic microtubule array that precedes the formation of the cleavage furrow and thus suggest that it plays a role in furrow positioning. This prefurrowing microtubule array was seen during the first two-cell division cycles. Following its positioning role we suggest that this array develops into furrow deepening array described previously. 1. R. Rappaport, 1996, Cytokinesis in Animal Cells. Chapter 7. The Stimulus–Response System, pp. 186–229, Cambridge Univ. Press; 2. S. Jesuthasan, 1998, J. Cell Sci. 111, 3695-3703.

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Lee et al., 2002 ZDB-PUB-021017-53

A microtubule array precedes the formation of the cleavage furrow during the first two-cell division cycles in zebrafish embryos

Lee et al., 2002

ZDB-PUB-021017-53