PUBLICATION
Hoxc13 orthologs in zebrafish
- Authors
- Thummel, R., Li, L., Sarras, M.P., and Godwin, A.R.
- ID
- ZDB-PUB-021017-49
- Date
- 2002
- Source
- Developmental Biology 247(2): 445 (Abstract)
- Registered Authors
- Thummel, Ryan
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none
Citation
Thummel, R., Li, L., Sarras, M.P., and Godwin, A.R. (2002) Hoxc13 orthologs in zebrafish. Developmental Biology. 247(2):445.
Abstract
Antennapedia-class homeobox-containing (Hox) genes are involved in anterior–posterior axis patterning. In addition, as celland region-specific selectors, they often play special roles in organ systems or in organogenesis. Zebrafish contain 47 Hox genes. This large number of Hox genes is due, in part, to a duplication of each Hox cluster. The result is 7 clusters in zebrafish (versus 4 clusters in mammals), and often, two zebrafish orthologs have diverged in structure, expression pattern, and function. We have chosen to analyze the two Hoxc13 orthologs in zebrafish for such divergence. We cloned and sequenced both genes and find regions of protein divergence, especially in the N-terminal region. We will also show that both Hoxc13 orthologs are expressed in the developing tail bud and will discuss differences in timing and apparent transcript level observed between both orthologs. Finally, to test the functional significance of both zebrafish Hoxc13 orthologs in the developing zebrafish tail bud, we have started experiments using morpholinomediated gene knockdown.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping