|ZFIN ID: ZDB-PUB-021016-12|
B cells develop in the zebrafish pancreas
Danilova, N. and Steiner, L.A.
|Source:||Proceedings of the National Academy of Sciences of the United States of America 99(21): 13711-13716 (Journal)|
|Registered Authors:||Danilova, Nadia, Steiner, Lisa|
|PubMed:||12370418 Full text @ Proc. Natl. Acad. Sci. USA|
Danilova, N. and Steiner, L.A. (2002) B cells develop in the zebrafish pancreas. Proceedings of the National Academy of Sciences of the United States of America. 99(21):13711-13716.
ABSTRACTThe zebrafish, with its transparent free-living embryo, is a useful organism for investigating early stages in lymphopoiesis. Previously, we showed that T cells differentiate in the thymus by day 4, but no sites for B cell differentiation were seen until 3 weeks. We report here that on day 4, we detect rearrangements of genes encoding B cell receptors in DNA extracted from whole fish. Also by day 4, rag1 transcripts are seen in the pancreas, an organ not previously associated with lymphopoiesis; by day 10, Igmu; transcripts are detected here. Thus, in zebrafish, the pancreas assumes the role of both the liver in fetal mice and the spleen in neonatal mice.