PUBLICATION

Convergence and extension in vertebrate gastrulae: cell movements according to or in search of identity?

Authors
Myers, D., Sepich, D. and Solnica-Krezel, L.
ID
ZDB-PUB-020905-1
Date
2002
Source
Trends in genetics : TIG   18(9): 447-455 (Journal)
Registered Authors
Myers, Dina, Sepich, Diane, Solnica-Krezel, Lilianna
Keywords
none
MeSH Terms
  • Animals
  • Body Patterning/physiology*
  • Bone Morphogenetic Proteins/physiology*
  • Cell Movement/physiology*
  • Embryo, Nonmammalian/physiology
  • Gastrula/physiology*
  • Gene Expression Regulation, Developmental/physiology*
  • Signal Transduction
  • Zebrafish/embryology*
  • Zebrafish/physiology
PubMed
12175805 Full text @ Trends Genet.
Abstract
During vertebrate gastrulation, convergence and extension cell movements both narrow and lengthen the forming embryonic axis. Concurrently, positional information established principally by the ventral-to-dorsal gradient of bone morphogenetic protein activity specifies cell fates within the gastrula. New data, primarily from zebrafish, have identified domains of distinct convergence and extension movements, and have established a role for the noncanonical Wnt signaling pathway in promoting the mediolateral cell polarization that underlies this morphogenetic process. Other observations suggest the intriguing possibility that positional information regulates convergence and extension movements in parallel with cell-fate specification.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes