PUBLICATION
Conserved function for embryonic nodal cilia
- Authors
- Essner, J.J., Vogan, K.J., Wagner, M.K., Tabin, C.J., Yost, H.J., and Brueckner, M.
- ID
- ZDB-PUB-020820-15
- Date
- 2002
- Source
- Nature 418(6893): 37-38 (Journal)
- Registered Authors
- Essner, Jeffrey, Nyholm, Molly Wagner, Yost, H. Joseph
- Keywords
- none
- MeSH Terms
-
- Animals
- Axonemal Dyneins
- Body Patterning*
- Chick Embryo
- Cilia/physiology*
- Conserved Sequence
- Dyneins/genetics
- Dyneins/metabolism*
- Embryo, Mammalian/cytology*
- Embryo, Mammalian/embryology*
- Embryo, Mammalian/metabolism
- Embryo, Nonmammalian*
- Gastrula/cytology
- Gastrula/metabolism
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Mice
- Organizers, Embryonic/embryology
- Organizers, Embryonic/metabolism
- Signal Transduction
- Vertebrates/embryology*
- Vertebrates/genetics
- Xenopus/embryology
- Xenopus/genetics
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish Proteins
- PubMed
- 12097899 Full text @ Nature
Citation
Essner, J.J., Vogan, K.J., Wagner, M.K., Tabin, C.J., Yost, H.J., and Brueckner, M. (2002) Conserved function for embryonic nodal cilia. Nature. 418(6893):37-38.
Abstract
How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping