ZFIN ID: ZDB-PUB-020820-15
Conserved function for embryonic nodal cilia
Essner, J.J., Vogan, K.J., Wagner, M.K., Tabin, C.J., Yost, H.J., and Brueckner, M.
Date: 2002
Source: Nature   418(6893): 37-38 (Journal)
Registered Authors: Essner, Jeffrey, Nyholm, Molly Wagner, Yost, H. Joseph
Keywords: none
MeSH Terms:
  • Animals
  • Axonemal Dyneins
  • Body Patterning*
  • Chick Embryo
  • Cilia/physiology*
  • Conserved Sequence
  • Dyneins/genetics
  • Dyneins/metabolism*
  • Embryo, Mammalian/cytology*
  • Embryo, Mammalian/embryology*
  • Embryo, Mammalian/metabolism
  • Embryo, Nonmammalian*
  • Gastrula/cytology
  • Gastrula/metabolism
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Mice
  • Organizers, Embryonic/embryology
  • Organizers, Embryonic/metabolism
  • Signal Transduction
  • Vertebrates/embryology*
  • Vertebrates/genetics
  • Xenopus/embryology
  • Xenopus/genetics
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish Proteins
PubMed: 12097899 Full text @ Nature
How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.