|ZFIN ID: ZDB-PUB-020820-15|
Conserved function for embryonic nodal cilia
Essner, J.J., Vogan, K.J., Wagner, M.K., Tabin, C.J., Yost, H.J., and Brueckner, M.
|Source:||Nature 418(6893): 37-38 (Journal)|
|Registered Authors:||Essner, Jeffrey, Nyholm, Molly Wagner, Yost, H. Joseph|
|PubMed:||12097899 Full text @ Nature|
Essner, J.J., Vogan, K.J., Wagner, M.K., Tabin, C.J., Yost, H.J., and Brueckner, M. (2002) Conserved function for embryonic nodal cilia. Nature. 418(6893):37-38.
ABSTRACTHow left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.
- Genes / Markers (1)