PUBLICATION
The role of the Eph-ephrin signalling system in the regulation of developmental patterning
- Authors
- Coulthard, M.G., Duffy, S., Down, M., Evans, B., Power, M., Smith, F., Stylianou, C., Kleikamp, S., Oates, A., Lackmann, M., Burns, G.F., and Boyd, A.W.
- ID
- ZDB-PUB-020807-5
- Date
- 2002
- Source
- The International journal of developmental biology 46(4): 375-384 (Journal)
- Registered Authors
- Boyd, Andrew W., Oates, Andrew
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Axons
- Cell Adhesion
- Cytoskeleton/metabolism
- Ephrins/metabolism*
- Gene Expression Regulation*
- In Situ Hybridization
- Ligands
- Mice
- Mice, Knockout
- Models, Biological
- Molecular Sequence Data
- Mutation
- Protein Structure, Tertiary
- Receptors, Eph Family/metabolism*
- Sequence Homology, Amino Acid
- Signal Transduction*
- Zebrafish
- PubMed
- 12141423
Citation
Coulthard, M.G., Duffy, S., Down, M., Evans, B., Power, M., Smith, F., Stylianou, C., Kleikamp, S., Oates, A., Lackmann, M., Burns, G.F., and Boyd, A.W. (2002) The role of the Eph-ephrin signalling system in the regulation of developmental patterning. The International journal of developmental biology. 46(4):375-384.
Abstract
The Eph and ephrin system, consisting of fourteen Eph receptor tyrosine kinase proteins and nine ephrin membrane proteins in vertebrates, has been implicated in the regulation of many critical events during development. Binding of cell surface Eph and ephrin proteins results in bi-directional signals, which regulate the cytoskeletal, adhesive and motile properties of the interacting cells. Through these signals Eph and ephrin proteins are involved in early embryonic cell movements, which establish the germ layers, cell movements involved in formation of tissue boundaries and the pathfinding of axons. This review focuses on two vertebrate models, the zebrafish and mouse, in which experimental perturbation of Eph and/or ephrin expression in vivo have provided important insights into the role and functioning of the Eph/ephrin system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping