PUBLICATION
A conserved family of doublesex-related genes from fishes
- Authors
- Huang, X., Cheng, H., Guo, Y., Liu, L., Gui, J., and Zhou, R.
- ID
- ZDB-PUB-020701-3
- Date
- 2002
- Source
- The Journal of experimental zoology 294(1): 63-67 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Conserved Sequence/genetics*
- DNA-Binding Proteins*
- Eels/genetics
- Female
- Fishes/genetics*
- Humans
- Male
- Molecular Sequence Data
- Phylogeny
- Sequence Alignment
- Sequence Analysis, DNA
- Sex Determination Processes
- Transcription Factors/chemistry
- Transcription Factors/genetics*
- Zebrafish/genetics
- Zebrafish Proteins*
- PubMed
- 11932949 Full text @ J. Exp. Zool.
Citation
Huang, X., Cheng, H., Guo, Y., Liu, L., Gui, J., and Zhou, R. (2002) A conserved family of doublesex-related genes from fishes. The Journal of experimental zoology. 294(1):63-67.
Abstract
The sex-determining gene Mab-3 of C. elegans and the doublesex gene of Drosophila each contain a common DM domain and share a similar role. Human doublesex-related gene DMRT1 also encodes a conserved DM-related DNA-binding domain. We present here the amplification of a broad range of DM domain sequences from three fish species using degenerate PCR. Our results reveal unexpected complexity of the DM domain gene family in vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping