PUBLICATION
Bioaccumulation of selected PCBs in zebrafish, three-spined stickleback, and Arctic char after three different routes of exposure
- Authors
- Andersson, P.L., Berg, A.H., Bjerselius, R., Norrgren, L., Olsén, H., Olsson, P.E., Örn, S., and Tysklind, M.
- ID
- ZDB-PUB-010718-20
- Date
- 2001
- Source
- Archives of environmental contamination and toxicology 40(4): 519-530 (Journal)
- Registered Authors
- Norrgren, Leif
- Keywords
- polychlorinated biphenyl congeners, trout Salmo gairdneri, rainbow trout, dietary uptake, food-web, fish, accumulation, biomagnification, bioconcentration, temperature
- MeSH Terms
-
- Administration, Oral
- Animals
- Diet
- Environmental Exposure
- Fishes*
- Infusions, Parenteral
- Polychlorinated Biphenyls/pharmacokinetics*
- Tissue Distribution
- Trout*
- PubMed
- 11525495 Full text @ Arch. Environ. Contam. Toxicol.
Citation
Andersson, P.L., Berg, A.H., Bjerselius, R., Norrgren, L., Olsén, H., Olsson, P.E., Örn, S., and Tysklind, M. (2001) Bioaccumulation of selected PCBs in zebrafish, three-spined stickleback, and Arctic char after three different routes of exposure. Archives of environmental contamination and toxicology. 40(4):519-530.
Abstract
The uptake and elimination of 20 structurally diverse tetra- to heptachlorinated biphenyls were studied in zebrafish (Danio rerio), three-spined stickleback (Gasterosteus aculeatus), and Arctic char (Salvelinus alpinus). The polychlorinated biphenyls (PCBs) were administered to the fish through food, intraperitoneal injection of peanut oil, or intraperitoneal implantation of silicone capsules. The retention of the PCBs in fish exposed through their diet was related with the substitution patterns of the compounds. Ortho-substituted congeners with no unsubstituted meta-para positions had high biomagnification potential. PCBs with low biomagnification all had adjacent vicinal hydrogens, indicating that congeners with this feature may have been metabolically eliminated. The retention characteristics of the PCBs in the diet-exposed and the injected zebrafish were similar. The pattern of congeners in Arctic char indicates that they have a lower capacity to metabolize PCBs compared to three-spined sticklebacks and zebrafish. The levels in the fish exposed to the PCBs through a silastic implant were negatively correlated with the hydrophobicity of the congeners. Most probably congener-specific release rates of the PCBs from the implants mask their retention characteristics. It is suggested that food, mimicking the natural intake route, should be used in PCB exposure studies to validate extrapolations to natural situations.
http://link.springer-ny.com/link/service/journals/00244/bibs/1040004/10400519.html
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping