| ZFIN ID: ZDB-PUB-010315-10 |
Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo
Holzschuh, J., Ryu, S., Aberger, F., and Driever, W.
| Date: | 2001 |
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| Source: | Mechanisms of Development 101(1-2): 237-243 (Journal) |
| Registered Authors: | Aberger, Fritz, Driever, Wolfgang, Holzschuh, Jochen, Ryu, Soojin |
| Keywords: | zebrafish; dopaminergic system; catecholaminergic system; tyrosine hydroxylase; dopamine transporter; diencephalon; olfactory bulb; pretectum; retina; locus coeruleus; medulla; carotid body; Parkinson's disease |
| MeSH Terms: |
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| PubMed: | 11231083 Full text @ Mech. Dev. |
Citation
Holzschuh, J., Ryu, S., Aberger, F., and Driever, W. (2001) Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mechanisms of Development. 101(1-2):237-243.
ABSTRACT
To characterize the formation of the dopaminergic system in the developing zebrafish CNS, we cloned cDNAs encoding tyrosine hydroxylase (th), an enzyme in dopamine synthesis, and the dopamine transporter (dat), a membrane transport protein which terminates dopamine action by re-uptake. Dopaminergic neurons are first detected between 18 and 19 h post-fertilization in a cluster of cells in the ventral diencephalon. Subsequently, th and dat detection identifies dopaminergic neurons in the olfactory bulb, the pretectum, the retina and the locus coeruleus. Neurons expressing th but not dat are adrenergic or noradrenergic, and are found in the locus coeruleus, the medulla, the likely analog of the carotid body, and precursors of the enteric and sympathetic nervous system.
ADDITIONAL INFORMATION
- Genes / Markers (2)
- Fish (1)
- Orthology (1)