PUBLICATION

The midbrain-hindbrain boundary organizer

Authors
Rhinn, M. and Brand, M.
ID
ZDB-PUB-010219-3
Date
2001
Source
Current opinion in neurobiology   11(1): 34-42 (Review)
Registered Authors
Brand, Michael, Rhinn, Muriel
Keywords
none
MeSH Terms
  • Animals
  • Chick Embryo
  • Fibroblast Growth Factors/physiology
  • Homeodomain Proteins/genetics
  • Mesencephalon/embryology*
  • Mice
  • Otx Transcription Factors
  • Rhombencephalon/embryology*
  • Zebrafish
  • Zebrafish Proteins
PubMed
11179870 Full text @ Curr. Opin. Neurobiol.
Abstract
Cell fate in the cephalic neural primordium is controlled by an organizer located at the midbrain-hindbrain boundary. Studies in chick, mouse and zebrafish converge to show that mutually repressive interactions between homeodomain transcription factors of the Otx and Gbx class position this organizer in the neural primordium. Once positioned, independent signaling pathways converge in their activity to drive organizer function. Fibroblast growth factors secreted from the organizer are necessary for, and sufficient to mimic, organizer activity in patterning the midbrain and anterior hindbrain, and are tightly controlled by feedback inhibition.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes