The midbrain-hindbrain boundary organizer
- Rhinn, M. and Brand, M.
- Current opinion in neurobiology 11(1): 34-42 (Review)
- Registered Authors
- Brand, Michael, Rhinn, Muriel
- MeSH Terms
- Chick Embryo
- Fibroblast Growth Factors/physiology
- Homeodomain Proteins/genetics
- Otx Transcription Factors
- Zebrafish Proteins
- 11179870 Full text @ Curr. Opin. Neurobiol.
Rhinn, M. and Brand, M. (2001) The midbrain-hindbrain boundary organizer. Current opinion in neurobiology. 11(1):34-42.
Cell fate in the cephalic neural primordium is controlled by an organizer located at the midbrain-hindbrain boundary. Studies in chick, mouse and zebrafish converge to show that mutually repressive interactions between homeodomain transcription factors of the Otx and Gbx class position this organizer in the neural primordium. Once positioned, independent signaling pathways converge in their activity to drive organizer function. Fibroblast growth factors secreted from the organizer are necessary for, and sufficient to mimic, organizer activity in patterning the midbrain and anterior hindbrain, and are tightly controlled by feedback inhibition.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes