PUBLICATION
The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites
- Authors
- Pasini, A., Henrique, D., and Wilkinson, D.G.
- ID
- ZDB-PUB-010219-15
- Date
- 2001
- Source
- Mechanisms of Development 100(2): 317-321 (Journal)
- Registered Authors
- Wilkinson, David
- Keywords
- zebrafish; embryogenesis; central nervous system; hindbrain; rhombomeres; segmentation; boundaries; Hairy/Enhancer-of-split genes; her genes; her6; krox20; bHLH proteins; somitogenesis; presomitic mesoderm; somites
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Brain/embryology*
- Chickens
- Cloning, Molecular
- DNA, Complementary/metabolism
- Embryo, Nonmammalian
- Humans
- Mesoderm/metabolism
- Mice
- Molecular Sequence Data
- Rats
- Repressor Proteins/biosynthesis*
- Repressor Proteins/genetics*
- Rhombencephalon/metabolism
- Sequence Homology, Amino Acid
- Somites/metabolism*
- Time Factors
- Transcription Factors/biosynthesis*
- Transcription Factors/genetics*
- Xenopus
- Zebrafish
- Zebrafish Proteins*
- PubMed
- 11165489 Full text @ Mech. Dev.
Citation
Pasini, A., Henrique, D., and Wilkinson, D.G. (2001) The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites. Mechanisms of Development. 100(2):317-321.
Abstract
Several vertebrate genes of the Hairy/Enhancer-of-split (HES) family are involved in paraxial mesoderm segmentation and intersomitic boundary establishment/maintenance. Here, we show that the zebrafish hairy-related gene, her6, highly homologous to the mammalian and chicken HES-1 genes, is expressed in the posterior part of each segmented somite and in stripes in the anterior presomitic mesoderm (PSM), and also in a dynamic, segmentally restricted pattern during hindbrain segmentation, with all rhombomeres expressing her6 at different time points and at different levels.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping