ZFIN ID: ZDB-PUB-010219-15
The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites
Pasini, A., Henrique, D., and Wilkinson, D.G.
Date: 2001
Source: Mechanisms of Development   100(2): 317-321 (Journal)
Registered Authors: Wilkinson, David
Keywords: zebrafish; embryogenesis; central nervous system; hindbrain; rhombomeres; segmentation; boundaries; Hairy/Enhancer-of-split genes; her genes; her6; krox20; bHLH proteins; somitogenesis; presomitic mesoderm; somites
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Basic Helix-Loop-Helix Transcription Factors
  • Brain/embryology*
  • Chickens
  • Cloning, Molecular
  • DNA, Complementary/metabolism
  • Embryo, Nonmammalian
  • Humans
  • Mesoderm/metabolism
  • Mice
  • Molecular Sequence Data
  • Rats
  • Repressor Proteins/biosynthesis*
  • Repressor Proteins/genetics*
  • Rhombencephalon/metabolism
  • Sequence Homology, Amino Acid
  • Somites/metabolism*
  • Time Factors
  • Transcription Factors/biosynthesis*
  • Transcription Factors/genetics*
  • Xenopus
  • Zebrafish
  • Zebrafish Proteins*
PubMed: 11165489 Full text @ Mech. Dev.
Several vertebrate genes of the Hairy/Enhancer-of-split (HES) family are involved in paraxial mesoderm segmentation and intersomitic boundary establishment/maintenance. Here, we show that the zebrafish hairy-related gene, her6, highly homologous to the mammalian and chicken HES-1 genes, is expressed in the posterior part of each segmented somite and in stripes in the anterior presomitic mesoderm (PSM), and also in a dynamic, segmentally restricted pattern during hindbrain segmentation, with all rhombomeres expressing her6 at different time points and at different levels.