ZFIN ID: ZDB-PUB-001205-9
Zebrafish Hsp40 and Hsc70 genes are both induced during caudal fin regeneration
Tawk, M., Joulie, C., and Vriz, S.
Date: 2000
Source: Mechanisms of Development   99(1-2): 183-186 (Journal)
Registered Authors: Vriz, Sophie
Keywords: zebrafish; caudal fin; regeneration; development; Hsp40; wound healing; blastema; chaperones; Hsc70; heat shock proteins; osteoblasts
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins/biosynthesis*
  • Carrier Proteins/genetics*
  • DNA, Complementary/metabolism
  • Gene Library
  • HSC70 Heat-Shock Proteins
  • HSP40 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins*
  • Heat-Shock Proteins/biosynthesis*
  • Heat-Shock Proteins/genetics*
  • In Situ Hybridization
  • Molecular Sequence Data
  • RNA, Messenger/metabolism
  • Regeneration
  • Sequence Homology, Amino Acid
  • Zebrafish/embryology*
  • Zebrafish/physiology*
  • Zebrafish Proteins
PubMed: 11091090 Full text @ Mech. Dev.
We report the characterization of a zebrafish DnaJ-like protein, homologue to the human Hsp40 protein hdj1, that we named zf-Hsp40. We have studied its expression during fin regeneration and we show that zf-Hsp40 mRNA level is drastically increased in all ray segments beneath the regenerated part, or blastema, in response to caudal fin amputation. In order to investigate whether zf-Hsp40 is part of a stress response system after injury, we studied the expression of the zebrafish Hsc70 transcript. Our results show a correlation between the expression of the two transcripts.