PUBLICATION

Building the vertebrate vasculature: research is going swimmingly

Authors

Roman, B.L. and Weinstein, B.M.

ID

ZDB-PUB-001101-6

Date

2000

Source

BioEssays : news and reviews in molecular, cellular and developmental biology 22(10): 882-893 (Journal)

Registered Authors

Roman, Beth, Weinstein, Brant M.

Keywords

none

MeSH Terms

Research
Zebrafish
Vertebrates
Mice
Animals
Veins/physiology
Neovascularization, Physiologic*
Arteries/physiology

PubMed

10984714 Full text @ Bioessays

Abstract

The vertebrate vasculature develops in remarkably similar fashion in all vertebrates. A cohort of unspecified mesodermal cells differentiates into primitive endothelial cells, which migrate to and occupy positions within the stereotypical blueprint of the primitive vasculature. Once in position, these cells coalesce and form cords, which lumenize and become ensheathed by supporting pericytes and smooth muscle cells. This primitive vascular network is extensively remodeled in some places, and expanded by sprouting in others. Various studies using the mouse, quail/chick, and frog have uncovered a number of signals that guide these complex processes but many gaps still exist in our understanding of the mechanisms by which the embryonic vasculature is built. Because many questions will require in vivo studies to be properly addressed, the zebrafish, with its unique accessibility to analysis by combined embryological, molecular, and genetic methods, should prove invaluable in identifying new molecules involved in blood vessel development and integrating pathways that influence embryonic blood vessel formation. BioEssays 22:882-893, 2000.

Genes / Markers

Figures

Expression

Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Antibodies

Orthology

Engineered Foreign Genes

Mapping

Roman et al., 2000 ZDB-PUB-001101-6 PMID:10984714

Building the vertebrate vasculature: research is going swimmingly

Roman et al., 2000

ZDB-PUB-001101-6
PMID:10984714