ZFIN ID: ZDB-PUB-000825-4
Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development
Yamamoto, A., Kemp, C., Bachiller, D., Geissert, D., and De Robertis, E.M.
Date: 2000
Source: Genesis (New York, N.Y. : 2000)   27(2): 49-57 (Journal)
Registered Authors: De Robertis, Eddy
Keywords: none
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Cadherins/biosynthesis*
  • Cadherins/genetics
  • Embryonic and Fetal Development/genetics
  • Gene Expression Regulation, Developmental
  • Mesoderm/metabolism*
  • Mice
  • Molecular Sequence Data
PubMed: 10890978 Full text @ Genesis
Summary: Paraxial protocadherin (PAPC) is a cell adhesion molecule that marks cells undergoing convergence-extension cell movements in Xenopus and zebrafish gastrulating embryos. Here a mouse homologue (mpapc) was identified and characterized. During early- to mid-gastrulation, mpapc is expressed in the primitive streak as the trunk mesoderm undergoes morphogenetic cell movements. At head-fold stage mpapc expression becomes localized to paraxial regions in which somites are formed in the segmental plate. At later stages, mpapc displays a complex expression pattern in cerebral cortex, olfactory bulb, inferior colliculus, and in longitudinal stripes in hindbrain. To analyze the effect of the loss of PAPC function during mouse development, a null allele of the mouse papc gene was generated. Homozygous animals show no defects in their skeleton and are viable and fertile.